Mumbai: The beleaguered Videocon Group has admitted to stupendous outstandings to various lenders – public and private – amounting to over Rs 90,000 crore, making it perhaps the biggest corporate bankruptcy case in Indian banking history, official sources said on Thursday. The two main group companies – Videocon Industries Ltd (VIL) and Videocon Telecommunication Ltd. (VTL) – owe Rs.59,451.87 crore and Rs.26,673.81 crore, respectively or a staggering Rs.86,125.68 crore to Indian banks, led by the State Bank of India (SBI). Also Read – India gets first tranche of Swiss bank a/c details Besides, 731 other Operational Creditors have made separate claims of Rs.31,117, 971,029 (VIL) and Rs.12,669,978,507 (VTL) for a total of over Rs 90,000 crore, the sources said. Interestingly, even the Group promoters – Venugopal Dhoot, Pradipkumar Dhoot and Rajkumar Dhoot – have also filed claims of Rs.57,823.24 crores on the basis of personal guarantees provided by them for various facilities availed/guaranteed by VIL, which are under evaluation. Also Read – Tourists to be allowed in J&K from Thursday The VTL has also claimed Rs.17,86,94,69,659 from VIL on which there is no dispute and has been accepted in toto. This and other data has been uploaded by the company’s Resolution Professional (RP) on its website today for varing periods ranging from November 2018 to January 2019. Industry sources say this will be the biggest private sector bankruptcy in India after the Insolvency and Bankruptcy Code was introduced in 2016 for debt resolution – with wide-ranging ramifications for both the corporate world and the banking sector. Last year, the company was sent by the SBI to the National Company Law Tribunal after the Dhoot-family owned company defaulted on its loans. As per the IBC regulations, the company’s board of directors has been suspended and a RP appointed to manage its routine daily operations. Revealing the figures of claims, VIL has named a whopping 54 Indian and foreign banks, financial institutions and even a cooperative bank to whom it owes a staggering Rs 59,451.87 crore. Against this, claims of Rs.57,443.62 crore have been admitted while claims of Rs 1,149.57 crore have been rejected and those worth Rs.782.24 crore are being verified. There’s the ICICI Bank with a claim of Rs 3,318.08 crore on VIL and another Rs 1,439 crore on VTL. It may be recalled that in January this year, the CBI had booked the then ICICI Bank Managing Director and CEO Chanda Kochhar, her husband Deepak Kochhar, VIL’s Venugopal Dhoot and others, in an alleged quid pro quo loan scam, for criminal conspiracy and cheating. Later that month, Chanda Kochhar quit but in a drastic action, she was sacked by the bank which also revoked all her entitlements and appointed a new COO, Sandeep Bakshi, in her place. On January 31, the Justice B.N. Shrikrishna Committee appointed to probe the scam found her guilty of flouting the ICICI Bank’s Code of Conduct as she failed to discharge her fiduciary functions to rescue herself to avoid any conflict of interest. Among the claims of VIL’s 54 lenders are 34 banks with SBI making the biggest claim of Rs.11,175.25 crore; from VTL’s total 34 lenders, SBI has claimed the highest amount of Rs 4,605.15 crore. From VIL, the second highest claimant is IDBI with Rs 9,561.67 crore crore. From VTL, the Central Bank of India is the second biggest claimant with Rs 3,073.16 crore. From VIL, the Latur Urban Cooperative Bank (Maharashtra) is the lowest claimant with Rs 33 lakh and from VTL, the lowest claim has been submitted by Bank of Maharashtra for Rs 21.13 crore.
San Francisco: As part of its efforts to curb the spread of false information, consipiracy theories and hate on its platform, Instagram is implementing a policy change concerning the removal of posts violating content norms based on accumulated negative strikes, as well as content bans. Instagram has said that with its new policy, accounts will be removed after an undisclosed amount of violations and an undisclosed window of time. And it’ll be the same bar for every user, regardless of how often they post on the app, Engadget reported on Wednesday. Also Read – Swiggy now in 500 Indian cities, targets 100 more this year Up until now, Instagram relied on a policy that allowed “a certain percentage” of violations within a window of time before it decides to ban someone. The company said it doesn’t want to share the exact number of strikes it will put in place, or the timeframe for them, because it doesn’t want bad actors to take advantage of the system, the report added. Earlier this week, the photo-messaging app decided to run posts going viral on its app through Facebook fact-checkers to ensure the credibility of the posts. Instagram also announced that it would soon allow users to appeal posts that have been taken down, directly from inside the app.
NEW YORK — The Latest on Ethiopian Plane Crash (all times local):4:05 p.m.The Transportation Department says it’s creating a special panel of experts to review Federal Aviation Administration procedures for approving new planes including the Boeing jet involved in two deadly crashes.The department said Monday the committee will be led by retired Air Force Gen. Darren McDew and Lee Moak, former president of the Air Line Pilots Association. Other members haven’t been named yet.Boeing and the FAA are already the subject of investigations by the Justice Department, the Transportation Department’s inspector general, and congressional committees.The FAA certified the Boeing 737 Max jet in 2017 and let it keep flying after a deadly crash in October in Indonesia that investigators believe may be related to a new flight-control system that pushed the plane’s nose down repeatedly. A second crash occurred this month in Ethiopia, leading regulators around the world to ground all Max jets.Preliminary satellite data indicates that both doomed planes made erratic climbs and descents before crashing shortly after takeoff. It’s likely to be months before investigators in Indonesia and Ethiopia issue conclusions on what caused the accidents.The Associated Press
These are indicative wholesale rates for foreign currency provided by the Bank of Canada on Thursday. Quotations in Canadian funds.Australia dollar 1.0010Brazil real 0.3995China renminbi 0.1894Euro 1.4837Hong Kong dollar 0.161659India rupee 0.01971Indonesia rupiah 0.0000950Japan yen 0.01151Malaysia ringgit 0.2944Mexico peso 0.07125N.Z. dollar 0.9234Norway krone 0.1590Peruvian new sol 0.3901Russia rouble 0.02136Saudi riyal 0.3372Singapore dollar 0.9264South Africa rand 0.09580South Korean won 0.001110Sweden krona 0.1558Switzerland franc 1.3121Taiwanese dollar 0.04169Thailand baht 0.03804Turkey lira 0.3594U.K. pound 1.6290U.S. dollar 1.2647Vietnam dong 0.000056
BEIJING — China has announced it will raise tariffs on $75 billion of U.S. products in retaliation for President Donald Trump’s planned Sept. 1 duty increase in a war over trade and technology policy.The official Xinhua News Agency said Friday the tariffs of 10% and 5% take effect on two batches of goods Sept. 1 and Dec. 15 but gave no details on what imports would be affected.Trump previously announced plans to raise tariffs on an additional $300 billion of Chinese imports on Sept. 1 but postponed a portion of that to Dec. 15.China’s government appealed to Trump this week to compromise in deadlocked talks aimed at settling the dispute that has battered exporters on both sides and threatens to tip the global economy into recession.The Associated Press
Senior forward Shayla Cooper dribbles past a Maryland defender in OSU’s game on Feb. 20 in the Schottenstein Center. Credit: Magee Sprague | Lantern reporterIn a team meeting on Feb. 9 about chemistry, relationships and late-season improvement, Ohio State senior forward Shayla Cooper addressed her teammates and laid out her vision for the team.“I brought it up to them like, ‘Hey, if we win 12 games in a row, which we’re very capable of — we’re national champions,” Cooper said. “If we win 11, we’re in that game, the national championship game.”Since the meeting, the Buckeyes are three games closer to the 12-0 goal set by Cooper, having defeated Iowa, Nebraska and, most recently, No. 2 Maryland on Monday, when Cooper was recognized as the lone senior on Senior Night.Cooper arguably played her best game of her career in the team’s 98-87 win over the Terrapins, putting OSU into a position to win the regular-season Big Ten title with a win over Rutgers on Sunday. She scored 20 points and had five assists, and led the team with nine rebounds.“It means a lot to be able to provide that for my team to secure the win, for one,” Cooper said. “They kept passing me the ball and hand down, man down — that’s what I’ve heard in the past, so I just let it rip.”Her performance on Monday was a long time coming for Cooper. And it wasn’t always easy. She was born in Birmingham, Alabama, living there until she moved to Tampa, Florida, in fifth grade when T-Mobile offered her mom a job in the Sunshine State. She picked up her first offer from a Division I program in eighth grade, when South Florida offered her a scholarship. After ninth grade, she moved to Georgia and the letters from college teams began flowing in.Cooper played high school basketball at Norcross High School (Georgia) with now Tennessee redshirt junior guard Diamond DeShields. Cooper and DeShields were competing for the limelight — an environment Cooper said she thrives in. But through those intense moments in practice, Cooper and DeShields formed an inseparable bond.DeShields, the Naismith High School Player of the Year in 2013, remembers nearly fighting with Cooper during a practice.“With her being one of my best friends, it was just kind of like a defining moment in our friendship and it made us closer, because I was able to see that she really wanted to win and she was able to see how much that I really wanted to win,” DeShields said.Cooper who transferred from Georgetown two games into the 2013-14 season after her coach was fired, brought the same competitive attitude to practices at OSU. Last season, she took pride in matching up with forward Stephanie Mavunga during the summer. Mavunga, who transferred to OSU from North Carolina after the 2014-15 season, was ineligible to play in 2015-16 due to NCAA transfer rules. Cooper took it upon herself to compete with the incoming 6-foot-3 post player whose only time on the court came during practice.“That was definitely fun, because I feel like I was the only one who would bring that competitiveness that she loves and I love,” Cooper said. “So we would trash talk to each other, but it was out of both of our competitive spirits.”Her competitive streak has been known to get her in trouble during games in the past.“A couple times I had to literally pull (Cooper) by her hair and be like, ‘Stop, you’re going to get a (technical foul), you’re going to get us in trouble,’” DeShields said.But as Cooper grew older, she matured and kept her emotions in check. DeShields has taken notice.“Shayla used to have a bit of a temper, which we used to always have to try to keep in check,” she said. “You definitely see that aspect of growth. She’s learned how to check herself when you can see her emotions flaring up.”Cooper challenged herself this season to communicate better with her teammates. Her tone varies for each player.“I might be able to get in (junior forward) Alexa (Hart) harder than I might be able to get into (junior guard) Asia (Doss),” Cooper said. “I might be able to go up to Alexa like, ‘Yo, what’re doing? You’re better than that.’ But Asia, I might have to pull to the side like, ‘Yo, I know you can do it,’ like on the softer tone.”She said she’s proud of her improvement in the area because, as someone who transferred, she understands players who feel like they don’t fit in. Cooper and redshirt junior guard Kianna Holland transferred to OSU in the same season and clicked instantly.“We were so close when we first got here, because it was like we didn’t know anybody and everybody is looking at us like, ‘Who are they?’” Cooper said.She didn’t want any of the three OSU freshmen — forward Tori McCoy, guard Jensen Caretti or guard Kiara Lewis — to feel the way she did. “Your freshmen are very important because if you don’t make them feel welcome, a lot of freshmen are transfers,” Cooper said.Mavunga, Holland, redshirt sophomore guard Sierra Calhoun, redshirt junior guard Linnae Harper and Cooper are all transfers who now play for OSU. But Cooper won’t be around after this season to reap the rewards. Cooper has her eyes set on the final games of 2017 and her OSU career. Cooper is eternally confident in herself and her team. She even espoused her desire for a rematch with No. 1 Connecticut (24-0), a team that beat No. 12 OSU 82-63 on Dec. 19, and currently owns the sport’s longest-ever winning streak at 101 games.“There are some things that we didn’t capitalize on,” Cooper said. “If we get another shot at them, I feel like we could beat them.”
← Previous Story THREE YEARS OF RIVALRY: GONZALES – JACOBSEN 5:2 Next Story → PASTOR HAS A KEY: PICK Szeged beat FC Barcelona Lassa Two great endings have been seen this afternoon in VELUX EHF Champions League. Niklas Ekberg took revenge to Celje Pivovarna Lasko with a goal eight seconds before the end for THW Kiel win – 28:27 (15:14). Swedish right wing netted seven goals for the first away win of his team in European elite competition this season, a week after shocking defeat in Sparkassen Arena…RK Celje Pivovarna Lasko: Lesjak (1.-60., 13/1 saves), Dobaj (1 save), Panjtar; Vujovic (5), Jurecic, Malus (1/1), Razgor (4), Suholeznik (2), Marguc (5), Groselj, Kodrin (3), Makuc, Anic (1), Dujshebaev (4/1), Mackovsek, Beciri (2); THW Kiel: Landin (1.-60., 14/1 saves), Wolff (n.e.); Firnhaber, R. Toft Hansen, Dissinger (n.e.), Wiencek (6), Ekberg (7/3), Zeitz (2), Frend Öfors (n.e.), Rahmel, Dahmke (3), Zarabec (1), Vujin (2), Bilyk (4), Nilsson (3); Cyril Dumoulin is the hero of Nantes once again! The fantastic French goalkeeper saved the last shot (16 saves in total) of Tin Kontrec for important win of HBC Nantes over RK PPD Zagreb 28:27.Nantes : Dumoulin 16 saves (37,21%), Siffert – Lagarde 4/4, Saurina 1/5, Faluvegi 1/4, Claire 3/7, Buric 6/7, Klein 3/5, Pechmalbec, Tournat 1/3, Feliho, Matulic 2/2, Lazarov 5/8, Gurbindo 1/1, Balaguer 1/2, Tuzolana. Zagreb : Kastelic 6 saves (31,58%), Skok 7/20 (35%) – Z. Markovic 3/6, Mrakovcic 2/2, Bozic, Kontrec 2/3, Vori 2/3, D. Markovic 1/2, Horvat 1/2 (1/1), Susnja 1/1, J. Valcic 2/4, T. Valcic, Mandalinic 5/12, Hrstic, Vuglac 2/8, Bicanic 6/7
Through his legislation the Minister is dictating the disposal of more than €2billion worth of assets, removing democratic input into the future provision of services, saddling Dublin City Council with €330million pension liability and providing no guarantee that water services will not be sold-off and/or privatised in the future.Read: Irish Water will not cut off supply to homes over unpaid chargesRead: Irish Water has ‘lot of work to do to provide safe drinking water’ DUBLIN CITY COUNCILLORS last night voted to defer the transfer of assets to Irish Water, saying that they were “extremely concerned” about the deal.At a special meeting of the council last night, a report was presented that showed that the council would hand over €2 billion worth of assets, but retain €330 million worth of pension liabilities.In a motion that was passed, councillors say that they wished to meet with Environment Minister Phil Hogan.Hogan had declined a request to attend the meeting, which showed that water charges for businesses in Dublin city will be increased, but the council will be unable to compensate business owners for the increase.The transfer of the assets is due to take place on 1 January, but the Service Level Agreement has not been agreed between Dublin City Council and Irish Water.This, the council claims, is because they have yet to see the final draft of the agreement.Fianna Fáil councillor Mary Fitzpatrick said that she felt Hogan was pushing the legislation through.“The Minister is railroading legislation through the houses of parliament this week which will directly impact Dublin cities commercial competitiveness.
Rafael van der Vaart revealed that Zlatan Ibrahimovic threatened to break his legs in their time together at Dutch side AjaxThe duo played alongside each other at the Amsterdam Arena for three years and often butted heads with each other.Before Ibrahimovic’s arrival in 2001, Van der Vaart was an established star within the Ajax team after graduating the club’s academy system.The two exciting youngsters would battle for supremacy the moment they were put into the same team.And, 14 years after Ibrahimovic left for Juventus, Van der Vaart has now revealed the extent of how sour their relationship became.Report: Van der Sar staying at Ajax for now George Patchias – September 12, 2019 Edwin van der Sar will not be leaving Ajax to take up a job at Manchester United.In the last few days, one bookmaker suspended…“Yes, he did say that, but Zlatan said it to everyone,” he told FourFourTwo.“It’s also true that around that time things just weren’t working between the two of us, but I would rather be in a team with people who are honest, like him, even if it means there are a few arguments.“But there wasn’t a specific moment we fell out – we generally didn’t get along well.”Both Van der Vaart and Ibrahimovic have had long careers at the top of football and are both in the twilight phases of their respective playing days.Nowadays Ibrahimovic plays for MLS side LA Galaxy, while Van der Vaart is in his third season of Danish football with Esbjerg.
Malaysian gaming giant Genting Berhad and Hard Rock International are among the global casino operators that could consider a takeover of Australia’s Crown Resorts, according to analysts from Deutsche Bank AG.The local arm of the investment bank also suggested private equity firms could show interest in a buyout following the events of the past 48 hours, which saw US-based casino operator Wynn Resorts terminate negotiations with Crown after news broke of private discussions. Wynn Resorts to undergo internal restructure as part of refinancing plan Lack of premium mass strategy begs questions of SJM’s Grand Lisboa Palace launch: analysts Wynn Resorts shares favored over Wynn Macau: analysts Load More While that US$7.1 billion deal is now off the table, the consensus among analysts and major Australian media outlets is that Crown is officially for sale with the company’s majority shareholder, James Packer, desperate to exit following a turbulent few years in which he has been forced to sell off key assets in both Macau and Las Vegas.Shares in Crown Resorts declined by around 9% following news that the Wynn deal was off, having surged by 20% when negotiations were first revealed just 24 hours earlier.However, Bernstein analysts also noted, “There’s no guarantee that any potential discussion around the [Wynn] deal will not resurface.”Discussing the possible motives for Wynn’s initial interest in Crown, Bernstein’s Vitaly Umansky, Eunice Lee and Kelsey Zhu added, “There may be solid synergies with respect to Chinese customers. We also see an acquisition as partly a possible defensive strategy for Wynn to fend off any potential acquirers.“While a transaction does expose Wynn to development risk of Crown Sydney, introduces Wynn to a slow growth Australian gaming market, increases debt, the synergies may be positive. A deal could also signal to Japan that Wynn is a larger, more serious candidate and Massachusetts may think twice about implementing harsh conditions on the license.” RelatedPosts
We weren’t kidding, Heinz Creme Egg Mayo is a thing! Who wants to try it?🙌 OF COURSE YOU DO! Come and see us at Ely’s Yard, Truman Brewery in London from 11th-13th April for free samples of this crazy combo. Only until stocks last! pic.twitter.com/3ZVehv0LJb— Heinz Mayo (@heinzmayo) April 2, 2019Heinz said the condiment is a great way to add flavor to waffles and cupcakes.The mayonnaise is not available on shelves just yet. Heinz is going to offer free tastings at a brewery in London from the 11th to the 13th.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. (WSVN) – For those of you looking for that … unique mixture of savory and sweet, Cadbury has teamed up with Heinz to concoct a special condiment.The two companies recently announced the creation of Cadbury creme egg-flavored mayonnaise.
In the face of substantial differences over a variety of issues in the House and Senate versions of the fiscal 2017 defense authorization bill, the lead staff for the congressional committees that produced the two measures said the bills aren’t as far apart as it may seem.“The objectives are the same, the intent is the same,” Chris Brose, staff director for the Senate Armed Services Committee, said Tuesday at an American Enterprise Institute event.One of the tougher issues that will need to be settled in conference is funding. While they both stick to the topline requested by the Obama administration for DOD’s base budget, the House adds $18 billion from the department’s overseas contingency operations account for base budget needs not requested by the Pentagon. That maneuver, though, would shortchange funding for overseas operations and force the next administration to request supplementary war funds before the end of April. As a result, the White House has threatened to veto the measure.Bob Simmons, staff director for House Senate Armed Services, defended the bill’s fiscal approach, pointing out that Democrats had used it in the past, reported Defense News.“We’re doing all these things to help the Department of Defense,” Simmons added. “If [the president is] going to veto it, he’s operating under false pretenses. We are taking care of the warfighter. We want to make sure those kids go into harm’s way with what they need.”The Senate version did not adopt the House framework, but Brose noted that SASC Chairman John McCain (R-Ariz.) also sought extra funds to pay for more equipment and higher force levels.“We have no disagreement over the need for this, and the challenge is how you deliver it with a topline both sides agree is inadequate,” Brose said.The Senate version also contains provisions that are opposed by the White House, including language that splits the position of undersecretary of defense for acquisition, technology and logistics into two posts — an undersecretary of defense for research and engineering and the renamed undersecretary for management and support.The committee’s reforms continue last year’s approach, which placed more acquisition authority in the hands of the services, Brose said. Dan Cohen AUTHOR
Now playing: Watch this: Smart Home Sport and Outdoors See also CES Products Tags Share your voice 1:22 Over-the-air wireless charging will come to the smartphone Samsung’s CES 2019 robots just want to give you a helping hand The weirdest, wackiest products from the show See all our CES coverage Post a comment These are the weirdest products of CES 2019 0 Download the app for Android or iPhone — it costs $15 per month or $149 per year — and complete Bowflex’s “fitness assessment.” This gives the software a baseline to determine the length and difficulty level that’s best for you.It also claims predictive capabilities that are supposed to automatically adjust your next workout based on your previous one. I got to try it out for myself and found the app fairly intuitive to navigate with straightforward workout stats and other data. Services like this are part of a growing trend in fitness equipment — tools to keep you motivated while you workout at home — and it isn’t the only home fitness device we’ve seen here at CES 2019. CES 2019 CNET Smart Home Bowflex Max Intelligence coaches you through your workout CES 2019: See all of CNET’s coverage of the year’s biggest tech show.CES schedule: It’s six days of jam-packed events. Here’s what to expect. 26 Photos The Bowflex Max Intelligence Platform service is supposed to keep you motivated when you exercise at home. Angela Lang/CNET Bowflex, makers of a wide range of fitness equipment, has something new for your home gym — the Max Intelligence platform. The Max Intelligence platform is an optional service that’s compatible with Bowflex’s Max Trainer M8 and M6 machines. The platform is supposed to act as a digital personal trainer in your home, keeping you motivated and adjusting your workouts for you based on your level of fitness.
Khammam: Some of TRS corporators have allegedly been plotting to move a no-trust motion against their own party Mayor G Papalal. Grapevine is abuzz that some TRS corporators had held a secret meeting recently to chalk out plans to unseat the Mayor. The dissident corporators have reportedly complained that development of Khammam city was hampered by the indifferent attitude of the Mayor. The corporators were even reportedly trying to garner the support of other parties to move a non-confidence against the Mayor. Also Read – Hyderabad: Intermediate student dies of cardiac arrest in class Advertise With Us The dissidents are understood to have secured the support of 35 out of 40 TRS corporators. There are total 50 corporators. According to sources, four senior corporators have been leading the revolt against the Mayor. Papalal, however, expressed confidence that it was not possible for dissident corporators to move a no-confidence against him now. Meanwhile, the Mayor’s supporters accused the dissident corporators of being notoriously corrupt.
Beetlejuice mutants (Prickle1Bj/Bj) develop median cleft lip and cleft secondary palate. (a,c) Frontal views of wild-type (Prickle1+/+) (a) and Prickle1Bj/Bj (c) at P0 (postnatal day). Median cleft lip indicated by arrow and is completely penetrant. (b,d) Palatal view of fetuses at embryonic stage 18.5 (E18.5). Arrow indicates medial cleft lip and cleft secondary palate. After collection the embryos and P0 fetuses were fixed in 4% paraformaldehyde and embedded in paraffin for histological/immunohistological analysis. Credit: Scientific Reports, doi: https://doi.org/10.1038/s41598-018-36742-0 By nature, the craniofacial complex contains three distinct regions: the skull vault, cranial base and the face. The cranial base forms the floor of the braincase and the skull vault – the roof. Bones of the cranial base form via endochondral ossification, while osteogenesis in the skull vault occurs via intramembranous ossification. Both the skull vault and cranial base are of embryonic origin (neural-crest derived or mesodermally derived). Embryological study of the skull reveals dinosaur-bird connection In contrast, in the homozygous mutant (PrickleBJ/BJ), contributions of the frontal bone to the total length increased, while the proportion of the parietal bone remained unchanged. Taken together, the results indicated that the Prickle1 protein function was required during all stages of frontal bone development. Wan et al. focused on the function of Prickle1 in the developing skull vault by examining the tissue distribution of the protein in wild type vs. mutant embryos. They found that the Prickle1 mutation resulted in two defected processes during frontal bone development, which included delayed osteoblast differentiation and reduced migration in the frontal bone. Such frontal bone defects were also observed in the phenotypic spectrum of cleidocranial dysplasia (CCD). The observed frontal bone insufficiency could potentially result from defects in proliferation and cell death. The scientists conducted studies using Haematoxylin and Eosin (H&E) histology dyes to test the hypothesis by observing frontal bone condensation in the wild type vs. mutant animals at embryonic stage 12.5 (E12.5), at which time frontal bone condensation typically occurred. Thereafter, they conducted TUNEL apoptosis assays, where the results indicated very few apoptotic cells (depicted via TUNEL positive uptake) in either genotype. Wan et al. further determined if a defective signaling system led to the observed delayed frontal bone osteogenesis by studying the level of canonical Wnt and Hedgehog (HH) signaling in the mutants. The results suggested that the levels of HH signaling (required for cranial bone development) were, indeed, defective in the mutant animals. Finally, they conducted in situ hybridization to markers of osteoblast migration (with markers Engrailed1 (En1), Twist1, Msx1 and Msx2) in the wild type and mutant littermates. The expression level of the markers was reduced in the frontal bone primordia in the mutants. The results suggested the Prickle1 protein function was necessary to mediate cell migration of osteoblast precursors during all stages of skull vault development. In this way, Wan et al. analyzed the Beetlejuice mutant mouse as a new model to understand the etiology of microcephaly. The number of animal models currently in use to determine the growth patterns of the face and skull in microcephaly are limited. The scientists combined genetic, molecular and physical mechanisms in the study relative to Prickle1 mutants to show contributions to decreased growth of the craniofacial region in the new mouse model. Wan et al. will continue the work to understand how cell migration and the alteration of each compartment (brain, skull vault and cranial base) contribute to the development of microcephaly, clavarial patterning and growth. Citation: The Prickle1 gene regulates the differentiation of frontal bone osteoblasts in a new animal model (2019, January 4) retrieved 18 August 2019 from https://phys.org/news/2019-01-prickle1-gene-differentiation-frontal-bone.html Homozygous mutants (PrickleBJ/BJ) are microcephalic and have defects in the neural-crest derived skull. (a-c, e-g) Macroscopic views of the wild type mouse (Prickle+/+) (a-c) and homozygous mutant (e-g) littermates. d) Schematic of the superior view of the skull vault, h) quantified skull vault measurements. The mutant heads are shorter proximal-distally when observed laterally from the external and with the alizarin red/alcian blue stained specimens. (c,g) Superior view of the skull vault demonstrates the interfrontal suture (yellow lines). d) Schematic of the skull vault showing the tissue origin, below which is the schematic for the measurement in (h). h) The proximal-distal shortening is most profound in the nasal region. Abbreviations: c: coronal suture, f: frontal bone, if: interfrontal suture, ip: interparietal bone, m: mesoderm, n: nasal bone, ncc: neural-crest cell, p: parietal bone, s: sagittal suture. Credit: Scientific Reports, doi: https://doi.org/10.1038/s41598-018-36742-0 Delayed ossification in the frontal bone primordium. Digoxigenin (DIG)-labeled section in situ hybridization to embryonic stage 12.5 Prickle1+/+ (a–c) and Prickle1Bj/Bj (d–f) littermates. The expression levels of Runx2 (a,d), Alkaline phosphatase (ALP) (b,e) and Osterix (c,f) are decreased in frontal bone primordium of Prickle1Bj/Bj mutants compared with wild-type control embryos. Credit: Scientific Reports, doi: https://doi.org/10.1038/s41598-018-36742-0 Explore further A mechanically compromised skull can result from enlarged fontanelles and smaller frontal bones due to defective migration and differentiation of osteoblasts in the skull primordia (developing skull). The Wnt/Planar cell polarity signaling pathway (Wnt/PCP), usually regulates cell migration and movement in tissues during embryonic development. In a recent study, conducted by Yong Wan and colleagues at the Center for Craniofacial Regeneration, the central research emphasis was on the Prickle1 gene, a core component of the Wnt/PCP pathway, in the skull. More information: Yong Wan et al. Prickle1 regulates differentiation of frontal bone osteoblasts, Scientific Reports (2018). DOI: 10.1038/s41598-018-36742-0 Osteogenesis: The Development of Bones. www.ncbi.nlm.nih.gov/books/NBK10056/Shiqin Zhang et al. Dose-Dependent Effects ofRunx2on Bone Development, Journal of Bone and Mineral Research (2009). DOI: 10.1359/jbmr.090502 Angel Pan et al. A review of hedgehog signaling in cranial bone development, Frontiers in Physiology (2013). DOI: 10.3389/fphys.2013.00061 S Mundlos et al. Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia, Cell (2004). DOI: 10.1016/S0092-8674(00)80260-3 The study included BrdU-labelled cell counts in the mutant vs. wild type mice to show no difference in the ratio of proliferating cells either. The number of actively dividing cells were then tested using phosphor-histone H3 immunohistochemistry to show no difference in the number of dividing cells in littermates. Since there was no change in cell death and proliferation, the scientists were next determined to test if osteogenic differentiation was occurring correctly.For this, Wan et al conducted RNA in situ hybridization experiments to assess the expression of alkaline phosphatase (ALP) and Osterix (OSX, also known as Sp7) in the pre-osteoblasts and osteoblasts of the frontal bones. They determined the expression of RUNX2, an early marker of osteoblast commitment in the skull and of ALP, a marker of more mature osteoblasts. By embryonic stage 15.5 (E15.5), the expression of Runx2, ALP and OSX decreased in the ectocranial layer of the mutant frontal bones compared with wild type littermates. The scientists determined that intramembranous ossification (conversion of mesenchymal tissue into bone) delayed in the frontal bone results in the hypoplastic Beetlejuice mutants. , Cell No change in the rate of proliferation or apoptosis in the Prickle1Bj/Bj frontal bones. At embryonic stage 12.5 (E12.5), Prickle1+/+ (a–d) and Prickle1Bj/Bj (f–i) littermates assayed for histology (haemotoxylin and eosin) staining (a,f), TUNEL staining (b,g), proliferation with BrdU immunofluorescence (c,h) and mitosis with phospho-histone H3 immunohistochemistry (d,i). (a,d) The frontal bone mesenchymal condensation (black outline) is present in both wildtype (a) and Prickle1Bj/Bj (f) littermates. (b,g) TUNEL-positive cells were found near the eye (arrowheads) and absent in the frontal bone primordia. (c,h) BrdU-positive cells (green) are found in the frontal bone primordium (white outline) of wildtype (c) and Prickle1Bj/Bj (h) littermates. (d,i) Few positive PHH3-positive cells (brown) are found in the frontal bone primordium of wildtype (d) and Prickle1Bj/Bj (i) littermates. (e) No difference in the ratio of BrdU-positive cells in the frontal bone primordia. (j) No difference in the number of PHH3-positive cells in the frontal bones between genotypes. Credit: Scientific Reports, doi: https://doi.org/10.1038/s41598-018-36742-0 Osteoblast migration is decreased in the frontal bone primordium. DIG-labeled section in situ hybridization to Twist1, Msx1, Msx2 and Engrailed1 (En1) to E12.5 Prickle1+/+ (a–d) and Prickle1Bj/Bj (e–h) coronal sections. (a,e) Decreased expression of Twist1 in the Prickle1Bj/Bj compared with wild-type. (b,f) The expression of Msx1 is decreased in the mutant compared with wild-type. (c,g) The expression of Msx2 is slightly decreased in the Prickle1Bj/Bj compared with wild-type. (d,h) The expression of En1 is similar in the Prickle1Bj/Bj compared with wild type. Credit: Scientific Reports, doi: https://doi.org/10.1038/s41598-018-36742-0 For the studies, Wan et al. used the missense allele of Prickle1, named Prickle1Beetlejuice (PrickleBJ). The homozygous PrickleBJ/BJ ‘Beetlejuice’ mutants were microcephalic and developed enlarged fontanelles between insufficient frontal bones, although the parietal bones were normal. The homozygous mutants had several other craniofacial defects including a midline cleft lip, incompletely penetrant cleft palate and decreased proximal-distal growth of the head. The scientists observed decreased Wnt/β-catenin and hedgehog signaling in the frontal bone condensations of the homozygous mutants in the study.The results are now published on Scientific Reports. In the homozygous mutants, the frontal bone osteoblast precursors underwent delayed differentiation, alongside decreased expression of migratory markers, resulting in underdeveloped frontal bones. The study showed that the Prickle1 protein function contributed to both migration and differentiation of bone-forming cells (osteoblast precursors) and its absence in the mutant animal model resulted in the defects. The homozygous mutants (PrickleBJ/BJ) developed cardiac outflow tract misalignment and cleft palate, contributing to perinatal death of the mutant mice. Therefore, the observed phenotypic features were from early to late embryonic stages. , Journal of Bone and Mineral Research In the study model, the Beetlejuice mutants (Bj) contained a point-mutation in the Prickle1 gene (C161F), the Bj C161F mutation was deleterious to the function of the cytoplasmic protein Prickle1. Mutations of the protein in humans are usually associated with familial epilepsy. The mutant phenotype was consistent with another independent point mutation of Prickle1, known as C251X, which included stunted limbs and a cleft palate. While the protein product of the gene is widely expressed in the cytoplasm, little was known about its role in craniofacial osteogenesis. In the present study, Wan et al. analyzed the bones and cartilage of the head using alcian blue and alizarin red histology dyes. The homozygous mutant skulls were smaller, and the proximal-distal length of the head was reduced with an increased medial-lateral width of the skull. The results showed a statistically significant decrease in the contribution of the nasal bone to the total length of the skull vault in the wild type mice (Prickle+/+). This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Journal information: Scientific Reports © 2019 Science X Network
Get the biggest Daily stories by emailSubscribeSee our privacy noticeThank you for subscribingSee our privacy noticeCould not subscribe, try again laterInvalid EmailUPDATE: 7.50pm: Lighting has now been restored at Kidsgrove. East Midlands and Network Rail have both confirmed. Trains can now call at the station. Trains are unable to stop at a town’s railway station this evening – for the second time in four days. A lighting problem at Kidsgrove railway station means trains are unable to stop there. So far East Midland trains and Northern Rail are both reported to be affected – with rail transport being arranged to the town from both Stoke-on-Trent and Macclesfield. There is no word yet on whether London Midland, the third company that serves Kidsgrove, is affected. Passengers travelling to the town are being advised to get off at Stoke-on-Trent station, where alternative transport is being arranged. The issue follows a similar incident affecting trains travelling to and from the station on Saturday evening. A spokesman for East Midlands Trains said: “Due to a problem with the station lighting at Kidsgrove, services between Derby and Crewe will not be calling there until further notice. Read MoreGovernment confirms city teachers to get help paying off student debt “We are arranging alternative transport from Stoke on Trent.” A Network Rail spokesman added: “Trains are unable to call at Kidsgrove due to a problem with station lighting. “Customers should travel to Stoke-on-Trent.”
Carnival Liberty, the first ship to feature the ‘Fun Ship 2.0’ initiatives – Image courtesy of minnemum – Flickr Source = e-Travel Blackboard: N.A Celebrity chef and star of the ‘Food Network’, Guy Fieri, is taking his hand-crafted burgers, fresh-cut fries and exclusive recipes created specifically for Carnival to the high seas. The free dining venue is set to debut onboard Carnival Liberty post refurbishments later this month before being rolled out to several other fun ships. Five different burgers will be on offer along with a wide array of condiments including chipotle mayonnaise, a special barbeque sauce, garlic aioli and three hot sauces at two self-serve stations. A variety of toppings including grilled onions, crumbled blue cheese and sautéed mushrooms will also be on offer in the car-themed venue taking inspiration from Guy’s California roots. Themed with life-size surfboards, car bumpers, grilles and car hoods, staff will wear mechanic uniforms adorned with personalised nicknames.“I’m stoked to be partnering with the team from Carnival. They understand what it takes to make a top notch burger – quality ingredients and a great attitude,” said Guy who appeared on stage in New York City this week to announce the partnership. “It’s great to see a cruise line adding additional food venues that aren’t at an extra cost to the passenger,” said creator of Cruise Radio, Doug Parker to e-Travel Blackboard live from the announcement in New York City. BlueIguana CantinaThis free poolside dining venue will offer passengers the opportunity to make their own freshly made burritos and tacos on homemade tortillas complete with an array of salsas and toppings. EA SPORTS BarPassengers will be able to play EA SPORTS video games, watch live sports on a video wall featuring 16 46-inch big screens and keep up to date with real-time sports results 24/7.Daily trivia games and EA SPORTS video game tournaments will be on offer along with drinks and bar snacks. RedFrog Rum BarTaking inspiration from one of Carnival’s most popular destinations, the Caribbean, casual attire is welcomed at this themed poolside version of ‘RedFrog Pub’ which debuted on Carnival Magic earlier this year. The bar will offer rum-based cocktails and an array of beers, including Carnival’s signature draught, ‘ThirstyFrog Red’.BlueIguana Tequila BarLocated poolside across from ‘RedFrog Rum Bar’, ‘BlueIguana Tequila Bar’ will be Mexican themed and will specialise in tequila-based cocktails and Mexican beers. Live entertainment will be positioned between both bars to entertain patrons. Alchemy BarThe vintage-themed cocktail ‘pharmacy’ will offer a unique experience for guests with ‘mixologists’ prescribing blends of interesting flavours from a variety of categories along with the opportunity to create custom cocktails. The Library BarAn intimate cocktails lounge featuring automatic wine dispensers and a quiet, relaxed atmosphere. The Cruise Radio boys interview Guy Fieri at Carnival’s announcement in New York City Comedian and TV personality, George Lopez, is Carnival’s new ‘curator of comedy’ and will be acting as a consultant to vet and hire the talent seen fleetwide in Carnival’s comedy clubs. Passengers will be able to view George Lopez at his stand-up best in-cabin via their televisions, experience the ‘Punchliner Comedy Brunch’ which will be offered on sea days and take part in a comedy-themed consumer contest, slated for 2012.“Carnival’s ships offer a huge audience that truly appreciates comedic performances and the onboard clubs are fantastic,” said George.“I intend to help build and nurture an understanding among up-and-coming comedic talent that these ships represent a phenomenal environment to work and gain experience.”The changes to the comedy clubs on board will roll out over the next year with George Lopez set to sail on a yet to be named Carnival ship in December.Hasbro, The Game ShowPassengers will be placed in the middle of their favourite Hasbro games including ‘Sorry Sliders’, ‘Simon Flash’, ‘Yahtzee Bowling’, ‘Operation’ and ‘Connect 4 Basketball’.Playlist ProductionsThese music-driven revues will incorporate a wide array of genres including ‘Motor City’, the R&B Motown sounds of the 1960s and 1970s, ‘Divas’ showcasing the iconic female entertainers, ‘Latin Nights, a fusion of latin culture, music and choreography and ‘The Brits’ offering music from the UK’s best.The thirty minute productions will feature high-tech LED staging and special effects.DJ IrieAward-winning DJ Irie has been named the ‘Official DJ’ of Carnival Cruise Lines as part of the 2.0 initiative. Creating and leading ‘DJ Irie’s Spin-iversity’ he will train and develop the musical skills and personalities of the onboard DJ talent. Dining and BarsGuy’s Burger Joint Friends of e-Travel Blackboard, Matt Basford and Doug Parker from Cruise Radio with George Lopez at the Carnival Cruise Lines announcement in New York City In the largest initiative ever undertaken by Carnival Cruise Lines, their fun ships will receive what the line is dubbing the 2.0 treatment with fourteen ships scheduled to receive the refurbishments through to the end of 2015. Costing USD $500 million and involving partnerships with celebrities including George Lopez and DJ Irie along with companies including EA Sports and Hasbro, Carnival is set to dramatically transform their onboard guest experience.EntertainmentPunchliner Comedy Clubs Presented by George Lopez Click here to view a photo gallery of what to expect from Carnival’s ‘Fun Ship 2.0’ initiatives.
April 02 , 2019 Australia: Costa Group upbeat for 2019 despite pro … Monsanto dealt first Australian lawsuit over cance … Chile opens for Australian almonds … South Africa: Maluma Symposium to draw larger inte … “The efforts of industry, government, community, and researchers in minimising the spread of this potentially devastating disease have been world class … But the reality is that Panama TR4 is here to stay and it will eventually spread. Therefore planning for the future is critical,” said ABGC chair Stephen Lowe. “ABGC believes that the TR4 Program is well worth investing in into the future.”To ensure it will be, ABGC and BQ have formed a group with the aim of developing a formal partnership agreement regarding the TR4 Program.The agreement will concern how the program would be designed, delivered, funded, and managed over the next four years.ABGC has also begun consulting with international banana growers on the new partnership agreement, specifically how the industry could fund its share.Lowe emphasized that while the disease was contained to a relatively small area in Far North Queensland for now, slowing the inevitable spread is beneficial for the banana industry as a whole. You might also be interested in In an attempt to restrict the spread of the destructive Panama disease TR4 in Australia, the Queensland government recently granted the Australian Banana Growers’ Council (ABGC) AUD$12.1 million (over US$8 million) in funding.However, starting this July it has asked that a cost-sharing arrangement be made between itself and the industry to continue efforts against the disease.Its funding currently aids the TR4 Management and Containment Program, run by Biosecurity Queensland (BQ), which has been key in restricting the pathogen’s spread.While TR4 usually spreads rapidly, since its original discovery in Tully Valley in March 2015, it has only been detected on two other farms, thanks to the joined efforts of ABGC, BQ, individual growers, researchers, and the wider community.During the crisis, a national levy and ABGC funds covered costs when the first infected farm, in addition to all of its operations, was shutdown to ensure containment.
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of Education’” That letter which is now held along with the rest of Matlovich’s papers at the GLBT Historical Society in San Francisco can be read here (roll over to zoom): Courtesy of Leonard Matlovich Papers Gay Lesbian Bisexual and Transgender Historical Society Unlike Brown v Board Matlovich’s case did not go to the Supreme Court After the Air Force began the proceedings to give him a general (not honorable) discharge Matlovich announced that he wanted the decision to be reviewed Although the review board had the option to overturn decisions in “most unusual circumstances” they refused to do so Matlovich went on to become a dedicated advocate for gay rights running for the San Francisco public office that had once been Harvey Milk’s In 1980 a judge ordered the Air Force to reinstate Matlovich and to give him five years’ worth of back pay on the grounds that the “most unusual circumstances” rule was too vague The two sides eventually settled but the story didn’t end there “He had a gift peculiar to someone who really only had a high-school education and knew nothing about the gay rights movement before he became one of its leaders of appreciating historical perspective” Bedwell says Matlovich died of AIDS in 1988 He was 44 His tombstone which does not bear his name echoes the sentiments of that TIME reader from 40 years ago: WHEN I WAS IN THE MILITARY THEY GAVE ME A MEDAL FOR KILLING TWO MEN AND A DISCHARGE FOR LOVING ONE Margaret Witt at Leonard Matlovich’s gravesite Courtesy Margaret Witt Matlovich’s influence was particularly strong on one case Margaret Witt a retired major in the Air Force Reserves was a flight nurse who was discharged from the service after being outed against her will during the “don’t ask don’t tell” era After suing Witt settled shortly after that law was repealed in 2010 She recalls that as a closeted member of the military she often thought of Matlovich’s story as proof that it was possible to be proud of one’s service and proud of one’s sexuality "I never thought Id be in that position but I think we all thought it could happen to us” Witt says "We all kept our own hidden libraries if you will even of books and grabbed for any articles we could find on what was happening We silently followed very closely anything that was happening The visibility of all of those folks was a huge influence whether they were aware of it or not" These days as the military begins to accept not only gay people but also transgender service members Bedwell often recalls something Matlovich told the reporters who swarmed his discharge hearing back in 1975: “Maybe not in my lifetime but we are going to win in the end” Read the full 1975 cover story here in the TIME Vault: The Sergeant v The Air Force Correction: The original version of this post misstated which court tried Margaret Witt’s case It was the Ninth Circuit Court of Appeals History Newsletter Stay on top of the history behind today’s news View Sample Sign Up Now How Gay Life in America Has Changed Over 50 Years June 26 1964 issue of LIFE magazine Caption reads: "A San Francisco bar run for and by homosexuals is crowded with patrons who wear leather jackets make a show of masculinity and scorn effeminate members of their world Mural shows men in leather" Bill Eppridge—LIFE Magazine June 26 1964 issue of LIFE magazine Caption for full-page photo reads: "Two fluffy-sweatered young men stroll in New York City ignoring the stare of a ‘straight’ couple Flagrant homosexuals are unabashed by reactions of shock perplexity disgust" Bill Eppridge—LIFE Magazine June 26 1964 issue of LIFE magazine Caption for top left photo reads: "When Hollywood police closed ‘gay’ haunts near Santa Monica Blvd bar Barney Anthony put up a sign warning homosexuals ‘I don’t like ’em’ he says ‘There’s no excuse They’ll approach any nice-looking guy Anybody does any recruiting I say shoot him Who cares’" Bill Eppridge—LIFE Magazine June 26 1964 issue of LIFE magazine Captions read: "A police 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