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A step closer to clinical predictors of inhalational anthrax

first_imgFindings from researchers at Northwestern University’s Feinberg School of Medicine may offer physicians further help in quickly and accurately distinguishing early inhalational anthrax from other respiratory conditions—a vitally important skill if a widespread anthrax emergency were to occur.The scientists, whose report is published in the Jul 31 issue of The Lancet, found that the definitive predictor of inhalational anthrax was the chest radiograph. The presence of mediastinal widening or pleural effusion was 100% sensitive (95% confidence interval [CI], 84.6-100.0) for inhalational anthrax, 71.8% specific (CI, 64.8-78.1) for inhalational anthrax when compared with community-acquired pneumonia (CAP), and 95.6% specific (CI, 90.0-98.5) for inhalational anthrax compared with influenza-like illness (ILI).The matched case-control study involved 47 historical cases of confirmed inhalational anthrax, 36 of them naturally occurring from 1880 through 1976 and 11 of them from the 2001 anthrax attack, and 376 cases of CAP or ILI seen in the emergency department of Northwestern Memorial Hospital, Chicago, between January 2000 and February 2003.Before comparing the anthrax patients with the controls, the authors compared laboratory, chest radiograph, and autopsy findings between the naturally occurring and the bioterorrism-related anthrax cases and found no significant differences. “The chest radiograph findings of the two case groups were remarkably similar,” according to the authors. An accompanying commentary points out that the similarity of the two anthrax groups suggests that “the weaponisation process might not influence disease progression.” The anthrax spores used in the 2001 attack were electrostatically charged to make them more easily dispersible, and they were covered with polymerized glass and silica to prevent clumping.In addition to the chest film findings, additional clinical characteristics found in the study to be more common in inhalational anthrax patients than in those with CAP or ILI included nausea, vomiting, pallor or cyanosis, diaphoresis, altered mental status, and elevated hematocrit levels. Similar results have been reported in other studies, but the authors of the present study point out that they included substantially more anthrax cases and used matched controls for comparison.The authors acknowledge several limitations of their study, including the fact that because they used historical reports for the anthrax cases, their measurements of predictor variables are “inherently incomplete.” That they found such clear similarity between the naturally occurring and the more recent, more completely documented bioterrorism-related cases may dispel this concern somewhat, however. They also point out the possibility of misclassification of some of the CAP and ILI controls in their study. Finally, they note that clinical characteristics of inhalational anthrax may be subtle or even absent early in the disease, which could have affected the results. Because of these limitations, “Studies using prospectively colleced information from controls should be done to corroborate, modify, or refute our findings,” they conclude.Kyriacou DN, Stein AD, Yarnold P, et al. Clinical predictors of bioterrorism-related inhalational anthrax. Lancet 2004 Jul 31;364(9432):449-52 [Abstract]See also:CDC document on distinguishing ILI from inhalational anthrax (Nov 9, 2001)http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5044a5.htmCDC interim guidelines for clinical evaluation of suspected anthrax cases (Nov 2, 2001)http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5043a1.htmArticle in Feb 1, 2003, Clinical Infectious Diseases: “Clinical features that discriminate inhalational anthrax from other acute respiratory illnesses”http://www.journals.uchicago.edu/doi/full/10.1086/346035last_img read more

Messi unlikely to change mind on Barca exit, says presidential candidate

first_imgLionel Messi is unlikely to change his mind about leaving Barcelona, the club’s presidential candidate Victor Font has said.Messi rocked Barcelona last month when his lawyers told the club he wanted to activate a clause in his contract that would allow him to leave for free before the 2020-21 season.The club disputed the claim saying the clause expired on June 10 — with La Liga also releasing a statement saying his contract was still valid — but Font is not optimistic about convincing Messi to stay another year. “I really hope the decision can be changed,” Font told Sky Sports. “It doesn’t seem likely, though… if that’s the case, the focus should be on making the transition as smooth as possible.”Messi loves the club and he wants to win, he wants to compete. He has been saying this for many, many years, it’s not just been for a few weeks.”Unfortunately the club has not been able to deliver on the promise of building a competitive team.”Messi, 33, last won the Champions League with Barcelona in 2015 and an 8-2 humiliation at the hands of Bayern Munich in the quarter-finals last month was the final straw for the six-times world player of the year. Messi, who failed to turn up for pre-season training on Monday, had previously labeled his side “weak” and “inconsistent” after surrendering the league title to rivals Real Madrid.The club has spent millions on players in the transfer market who have not come good in recent years and transfer strategy is something Font hopes to change if he is elected president.”Currently you have the president, the chairman of the board and even some directors making decisions about signings, about selling players and that needs to be changed,” Font, who hopes to succeed president Josep Maria Bartomeu in the election next March, added.”That’s why we’ve been working on a project and we need people to lead that who come from the world of football.”Lionel Messi’s father and agent headed to Barcelona on Tuesday for what Argentine media said was a meeting with club president Josep Maria Bartomeu.TV pictures showed Jorge Messi boarding a private plane in Rosario.The plane was destined for the United States, from where he would proceed to Spain, local newspapers Ole and Capital de Rosario reported. center_img Topics :last_img read more

I Was a Transgender Woman

first_imgPublic Discourse 1 April 2015It was a pivotal scene. A mom was brushing a boy’s long hair, the boy slowly turned his head to look at her. In a tentative voice, he asked, “Would you love me if I were a boy?” The mom was raising her boy to become a trans-girl.In that split second, I was transported back to my childhood. I remembered my grandmother standing over me, guiding me, dressing me in a purple chiffon dress. The boy in that glowing documentary about parents raising transgender kids dared to voice a question I always wanted to ask. Why didn’t she love me the way I was?I am haunted by that boy and his question. What will the trans-kids of 2015 be like sixty years from now? Documentaries and news stories only give us a snapshot in time. They are edited to romanticize and normalize the notion of changing genders and to convince us that enlightened parents should help their children realize their dreams of being the opposite gender.I want to tell you my story. I want you to have the opportunity to see the life of a trans-kid, not in a polished television special, but across more than seven decades of life, with all of its confusion, pain, and redemption.The Trans-KidIt wasn’t my mother but my grandmother who clothed me in a purple chiffon dress she made for me. That dress set in motion a life filled with gender dysphoria, sexual abuse, alcohol and drug abuse, and finally, an unnecessary gender reassignment surgery. My life was ripped apart by a trusted adult who enjoyed dressing me as a girl.My mom and dad didn’t have any idea that when they dropped their son off for a weekend at Grandma’s that she was dressing their boy in girls’ clothes. Grandma told me it was our little secret. My grandmother withheld affirmations of me as a boy, but she lavished delighted praise upon me when I was dressed as a girl. Feelings of euphoria swept over me with her praise, followed later by depression and insecurity about being a boy. Her actions planted the idea in me that I was born in the wrong body. She nourished and encouraged the idea, and over time it took on a life of its own.Walt Heyer is an author and public speaker with a passion to help others who regret gender change. Through his website, SexChangeRegret.com, and his blog, WaltHeyer.com, Heyer raises public awareness about the incidence of regret and the tragic consequences suffered as a result. Heyer’s story can be read in novel form in Kid Dakota and The Secret at Grandma’s House and in his autobiography, A Transgender’s Faith. Heyer’s other books include Paper Genders and Gender, Lies and Suicide.http://www.thepublicdiscourse.com/2015/04/14688/last_img read more

Sperm donor shortage leaves women waiting two years

first_imgNZ Herald 22 October 2017Family First Comment: Fortunately, men seem to be understanding the long-term ramifications of this process – both for themselves and for the child who will want to know their biological father one day. But this bit is interesting…“We’ve always had heterosexual couples and lesbian couples looking for sperm donor treatment but the biggest phenomenal change has been in the number of single women coming.”But fathers matter…Fatherlessness is an issue for children.Sperm donors are in hot demand with the shortage of donors the worst it has ever been in New Zealand.About 450 women are on the waiting list for a donor at Fertility Associates, which has clinics throughout the country, with the wait time sitting at about two years.At Auckland’s Fertility Plus the wait time is just as long and there is an official wait list of about 40 women but scientific director Margaret Merrilees said she believed there were many more women who would put their names forward if there were more donors.“We are desperately short of donors,” she said.Medical director of Fertility Associates Auckland Simon Kelly said women waiting for donor sperm for IVF treatment could expect to wait about a year while the wait for women wanting sperm to be inserted straight into the uterus to allow for a more natural impregnation was about two years.He said the shortage was the worst it had ever been despite having seen an increase in donors in recent years.Single women looking to start a family on their own were behind the growing demand, he said.“It’s a change in society. A lot more women in their mid-to-late 30s are coming in as single women looking for treatment. People are leaving having families until later and that’s reflected in the numbers of single women we are seeing.”Kelly said they had noticed a “dramatic” increase in demand from single women during the last four or five years, he said.“We’ve always had heterosexual couples and lesbian couples looking for sperm donor treatment but the biggest phenomenal change has been in the number of single women coming.”The long wait time meant the clinic often encouraged women to see if they could find their own personal donor to speed up the process, he said.Kelly estimated another 200 sperm donors would be needed just to cope with the current demand but said that would involve screening double the number of men to find enough suitable donors.He said the clinic usually had about 50 donors at any one time. Under New Zealand law donors could provide sperm to up to five families. Since the clinic was set up in 1987 more than 2000 men had donated sperm, he said.The law in New Zealand also stipulated donors could be compensated for expenses like travel and parking but could not be paid for donating. It was also an open process which meant once the child turned 18 they were able to access their records and get in touch with their biological father.Kelly said both of those factors made it harder to attract sperm donors.READ MORE: http://www.nzherald.co.nz/index.cfm?objectid=11934847&ref=twitterlast_img read more

Cuban lung cancer vaccine to be tested in US

first_img Tweet Share Share HealthLifestyleNewsRegional Cuban lung cancer vaccine to be tested in US by: Caribbean Media Corporation – May 9, 2016 Sharecenter_img Sharing is caring! The Cuban vaccine known as Cimavax (Photo: CMC)HAVANA, Cuba (CMC) – A lung cancer vaccine developed in Cuba will be tested in the United States through the work of the Rosewell Park Institute – a cancer research and treatment centre located in New York.The vaccine, known as Cimavax will soon enter the US and could benefit cancer patients in that country.“We believe that treatments should be available to all patients and that politics and geography should not prohibit the drug development process,” reads a statement on the webpage of the Washington based Lung Cancer Alliance.“The development of Cimavax is particularly exciting as it would represent a new class of therapeutics for lung cancer – a vaccine that primes the immune system, similarly to the flu shot or common childhood vaccines,” the statement continued.The Lung Cancer Alliance was founded in 1995 to meet the needs of lung cancer patients and those at risk by improving outcomes, eliminating stigma and securing public health research funding.In 2010 Lung Cancer Alliance began its first awareness program. Since then, Lung Cancer Alliance has developed many programs focused on lung cancer awareness: “Give a Scan,” “National Shine a Light on Lung Cancer,” and “Team Lung Love,” have helped create awareness in the United States and internationally.In February 2012, Lung Cancer Alliance took on its first major initiative, creating a national framework for lung cancer screening.In June 2012, it launched its national “No One Deserves To Die” campaign to help raise awareness and change the stigma associated with lung cancer. By the end of the campaign, more than 281 million impressions were made and market research proved a shift in sentiment around lung cancer. 165 Views   no discussionslast_img read more


first_img“We need to double our efforts inmonitoring the entry of illegal drugs. We expect a high demand for them thisChristmas season when most people have money,” said Tablate. “We will be utilizing 10 K-9 dogsaside from partnering with the police,” said Tablate. Of particular concern to the PDEA arethe seaports where drug traffickers are known to slip their stocks. Party drugs, also called club drugs orrave drugs, are recreational drugs that have stimulating properties. Regularuse can lead to the user craving more of the drug, resulting to addiction. “K-9” (a homophone of“canine”) are dogs trained to assist law enforcers detect contrabands such asillegal drugs and explosives. In Bacolod City and Negros Occidental,however, said Tablate, drug trafficking remains a challenge. PDEA-6 regional director Alex Tablate ILOILO City – Demand for party drugsis expected to surge this holiday season, according to the Philippine DrugEnforcement Agency (PDEA) Region 6. “I call on the community to help us in ourcampaign against illegal drugs. Malakingtulong kayo by giving us information about those into the illegal drugtrade,” said Director Alex Tablate. center_img In the worst cases, party drugs canresult in the death of the user from cardiac arrest or water intoxication dueto the increase in heart rate and thirstiness induced. PDEA will also be focusing on partyplaces where party drugs may be traded and used most especially by youngsters,he added. Party drugs have adverse effects tohealth and behavior. Among these are increased heart rate, a steep increase inbody temperature, increase in blood pressure, spasms and dehydration, breathingand respiratory issues, drowsiness, nausea and confusion, anxiety, stress, evenhallucination. The PDEA director, however, stressedthe supply of illegal drugs in Iloilo significantly dropped following thedeaths of drug lords Melvin “Boyet” Odicta Sr. in August 2016 in BarangayCaticlan, Malay, Aklan and Richard “Buang” Prevendido in September 2017 inBarangay Balabago, Jaro district here. “Our office will not stop going aroundchecking areas if party drugs are being used,” Tablate said. “Please help us in our campaign. Giveus information. PDEA and the police could not stop drug trafficking without thehelp of the community,” he stressed./PNlast_img read more

Man Utd midfielder drawing fitness inspiration from Ronaldo

first_img Promoted Content6 Incredibly Strange Facts About HurricanesBirds Enjoy Living In A Gallery Space Created For ThemWhat Is A Black Hole In Simple Terms?Everything You Need To Know About Asteroid ArmageddonBest & Worst Celebrity Endorsed Games Ever MadeBest Car Manufacturers In The WorldCouples Who Celebrated Their Union In A Unique, Unforgettable WayThese Are The Best Stargazing Locations You Can Find On EarthCan Playing Too Many Video Games Hurt Your Body?Did You Know There’s A Black Hole In The Milky Way?Which Country Is The Most Romantic In The World?5 Of The World’s Most Unique Theme Parks Loading… Manchester United midfielder, Scott McTominay, has been following Cristiano Ronaldo’s fitness regime during the UK’s coronavirus lockdown. “You don’t get any better than that. For me, looking up to somebody like that, the physique he’s got, the way that he applies himself. “I have just seen a picture of him, two days ago, reading and revising different things that he’s trying to learn in his life off the pitch. read also:Battle of Trafford: McTominay stunner finishes Man City “People are just far too comfortable too quickly in their life.” FacebookTwitterWhatsAppEmail分享 Juventus star Ronaldo, 35, prides himself on staying in top physical and mental condition – and McTominay has become a student of the Portuguese star on social media. Talking on the official Manchester United podcast, McTominay said: “You look at Ronaldo and guys like this – and their mentality is at the top of the top.Advertisementlast_img read more

Emam: How dispute over image rights affected Salah during 2018 World Cup

first_img Salah had guided Egypt to their first World Cup after a 28-year absence, however, the Egyptian had a disastrous build-up to the tournament. The 27-year-old had a public spat with former EFA president Hany Abou-Rida over the use of his image on the team’s plane without Salah’s permission. To make matters worse, Egypt finished bottom of their group in the World Cup after failing to win any of their matches. “Mohamed Salah had a disagreement with the former president of the federation, Hany Abou-Rida,” Emam said.Advertisement “We should have asked Salah before using his image on the national team’s aeroplane before the World Cup, that was the beginning of the whole problem”. “This disagreement had a bad influence on Salah during the World Cup. As a result. he did not celebrate his goals,” he added. read also:Ramadan Kareem: Pogba , Salah, Ozil, others send out wishes to fans Salah had travelled to Russia carrying a shoulder injury he sustained during Liverpool’s 3-1 defeat against Real Madrid in the 2018 UEFA Champions League final. The former Roma winger was forced to sit on the bench for Egypt’s opening game against Uruguay, but started in games against Russia and Saudi Arabia, scoring just two goals in the World Cup. FacebookTwitterWhatsAppEmail分享 Loading… Former Egyptian Football Association (EFA) member, Hazem Emam, has lamented Mohamed Salah’s 2018 World Cup performances, saying it was due to dispute over image rights. Promoted Content9 Iconic Roles That Could Have Been Played By Different Actors7 Ways To Understand Your Girlfriend Better7 Reasons Why You Might Want To Become A Vegetarian10 Extremely Dirty Seas In The WorldAlbino Animals: A Rare Kind Of Ultimate Beauty6 Interesting Ways To Make Money With A DroneBest & Worst Celebrity Endorsed Games Ever MadeBirds Enjoy Living In A Gallery Space Created For Them18 Cities With Neverending Tourist-Flow6 TV Shows That Got Better After A Major Character Had LeftYou’ve Only Seen Such Colorful Hairdos In A Handful Of Anime8 Superfoods For Growing Hair Back And Stimulating Its Growthlast_img read more

Wisconsin finally nets victory over Wayne State

first_imgBrooke Ammerman one-upped a hat trick, scoring four times against Wayne State on Friday night.[/media-credit]It was a scoring frenzy as the Wisconsin women’s hockey team downed the Wayne State Warriors 6-2 at the Kohl Center Friday afternoon. Finally, the Badgers outplayed an inferior opponent, almost doubling the Warriors shots-on-goal (38 to 20) and dominating puck possession.With the return of freshman forward Brianna Decker and junior defender Malee Windmeier, the Badgers seemed to skate with more confidence and kept things simpler throughout the game.Right from the start of the game it was all Badgers. Forty-two seconds in, UW sophomore forward Brooke Ammerman found the back of the net off an assist from Decker.“I hopped off the bench and the girl tried to pass across the ice,” Decker said of the goal. “I read that play. I ended up putting my stick back behind me and it hit the stick and [Ammerman] walked in and shot in the goal.”It did not take too long for Wayne State to retaliate. The Warriors took advantage of their first power play as forward Katrina Protopapas evened things up at 1-1 in the sixth minute. The Badgers bounced back, however, as Windmeier slipped the puck between Warriors goalie Lindsey Park’s legs on a shorthanded goal in the 16th minute of the first period.Head coach Tracey DeKeyser was pleased to see the shorthanded goal and noted Windmeier’s ability to make those exciting plays.“[Windmeier] is getting stronger, and you know that’s what [she] can do. She’s really perceptive, and she basically undressed that play all the way,” DeKeyser said.In the second period, the Badgers continued to outplay the Warriors, only allowing two shots on goal to 14 of their own. Wisconsin also utilized its third power play, as Ammerman knocked in her second goal of the game, putting the team ahead 3-1 in the 15th minute of the period.But Ammerman was not the only Badger to get a power-play goal. Decker also benefited from the man advantage, as she scored a goal in her first game back, 12 minutes into the third period off an assist from freshman defender Saige Pacholok.Pacholok noted the strong energy Decker brings to the team and her ability to bring the energy everywhere, particularly during this weekend series.“She’s brings a positive attitude to the bench and in game play on the ice, too,” Pacholok said. “She’s a clutch player — she really brings energy everywhere. It was really good to have her back.”Wayne State was not ready to let Wisconsin walk away with the win, though. Two minutes after Decker’s goal, Warriors forward Julie Ingratta slid in Wayne State’s second goal past Badgers goalie Alannah McCready, showing the Badgers they still had some fight in them.But Wisconsin was quick to shut them down. Again, just two minutes later, Ammerman knocked in her third goal of the game off assists from Pacholok and junior forward Mallory Deluce. Not only did Ammerman get a hat trick in the game, she went one goal further. With eight seconds left in the game, Ammerman found the back of the net for a fourth time off assists from Pacholok and freshman forward Breann Frykas, securing the 6-2 Wisconsin victory.“Brooke can finish,” DeKeyser said. “[She] had different linemates today, and that helps in terms of just trying something new and going to net. Both her and Decker are very good offensive threats, and so I think that 1-2 punch was the difference for our group today.”Ammerman mostly attributed her successful day to being in the right place at the right time.“I was just around the net — I got lucky the puck was coming to my stick. That first goal was nice to have by Decker, and the rest were just in front of the net and being in the right place at the right time.” Ammerman said.Overall, the team looked stronger and more dynamic. The Badgers had been having issues with scoring on their power plays, but profited off 2-of-5 opportunities in the game. The team also looked more confident and took control of the entire game as a whole.“I think we’re just coming together more as a team,” McCready said. “We have Decker back — it’s a good uplifter for the team. We’re finally starting to come together again and get things rolling and start playing how we know we can play with the talent that we have.”last_img read more

Students rally to support football team

first_imgWe are ’SC · Keyshawn Johnson, alumnus and former NFL player, spoke to players and students after the team’s practice Thursday. Jackson Dahl, a senior majoring in business administration, organized the rally for students to attend the practice before the team faces Notre Dame. – Maya Dondonayan | Daily TrojanAs USC football players left Howard Jones field after practice on Thursday, they were met with cheers, applause and chants of “We are SC!” and “Beat the Irish!” from students  on the sidelines.Students gathered for the team’s final practice before heading to face Notre Dame as part of a rally organized by Jackson Dahl, a senior majoring in business administration.“I was talking with a close friend and mentor Professor [David] Belasco, who has a lot of connections to the athletic program, and we were thinking, ‘It’s been a really rough week — it’s been a really rough four years,’” Dahl said. “We were thinking, ‘What could we do that would be really special?’ — hopefully lift [the team] a little bit as they go off to Notre Dame for probably the toughest game of the year.”Belasco, co-director and adjunct professor at the Lloyd Greif Center for Entrepreneurial Studies in the Marshall School of Business who teaches the popular class “The Leap,” said the idea for the rally came to him on Tuesday night.“I went here, I teach here. This is why they call it a Trojan Family -— we show up for each other when we need it,” he said. “This team has been through so much beyond their control over the last few years between sanctions and abrupt coaching changes that we just felt we needed to tell them, ‘It’s our team, it’s our University,’ and show up for them.”Belasco spoke to J.K. McKay, senior associate athletic director for football, and reached out to Dahl to get students involved. Dahl created a Facebook event for the rally and sent out emails to generate awareness.“When you want anything done, you get students involved quickly,” Belasco said. “You can tell that students were ready to receive this and support this because they all feel the same way: ‘What can we do to show our support for these players?’”Students joined the players in the huddle after practice where several former NFL football players who played for USC — Keyshawn Johnson, Willie McGinest and Keith Rivers — gave motivational speeches to the team.“It wasn’t us reaching out to the Trojan Family, it was the [Trojan Family] reaching out to us,” interim head coach Clay Helton said. “That’s what makes the hair on the back of your neck stand up.”More than 500 students said they would attend the rally on Facebook, but actual attendance was closer to 50. Will Orr, a senior majoring in law, history and culture said that while he was slightly disappointed with the turnout, he was glad to be able to support the team.“Two years ago, we said ‘one team, one heart,’ and I think that message still rings true,” he said. “I think Helton’s a helluva coach, and I think we’re going to finish the season strong, the team’s really coming together.”Eric Hahn, a sophomore majoring in international relations and global business, said the turmoil surrounding USC football earlier in the week drove him to attend the rally.“We had a tough week, a lot of stuff’s gone down,” he said. “Sark’s gone, but the one thing that brings us together is football and the Trojan Family, so it’s always worth coming out and supporting our guys.”Dahl said he is considering hosting more rallies in the future.“[Today’s rally] was super grassroots. We planned it the day before, but it’d be cool to see something happen with a little more momentum,” he said.last_img read more